| Модель | Enigne | CC | КВт | Цилиндр | Тип | Круглый год |
| MERCEDES-BENZ S-CLASS (W221) S 420 CDI (221,028, 221,128) | OM 629,911 | 3996 | 235 | 8 | Седан | 2006-2009 |
| MERCEDES-BENZ S-CLASS (W221) S 350 BlueTec (221,026, 221,126) | OM 642,862 | 2987 | 190 | 6 | Седан | 2011-2013 |
| MERCEDES-BENZ S-CLASS (W221) S 320 CDI (221,022, 221,122) | OM 642,930 | 2987 | 173 | 6 | Седан | 2005-2009 |
| MERCEDES-BENZ S-CLASS (W221) S 65 AMG (221,179) | M 275,982 | 5980 | 463 | 12 | Седан | 2011-2013 |
| MERCEDES-BENZ S-CLASS (W221) S 65 AMG (221,179) | M 275,982 | 5980 | 450 | 12 | Седан | 2005-2013 |
| MERCEDES-BENZ S-CLASS (W221) S 63 AMG (221,074, 221,174) | M 157,980 | 5461 | 420 | 8 | Седан | 2012-2013 |
| MERCEDES-BENZ S-CLASS (W221) S 63 AMG (221,074, 221,174) | M 157,980 | 5461 | 400 | 8 | Седан | 2011-2013 |
| MERCEDES-BENZ S-CLASS (W221) S 63 AMG (221,077, 221,177) | M 156,984 | 6208 | 386 | 8 | Седан | 2006-2013 |
| MERCEDES-BENZ S-CLASS (W221) S 600 (221,176) | M 275,953 | 5513 | 380 | 12 | Седан | 2005-2013 |
| MERCEDES-BENZ S-CLASS (W221) S 500 (221,071, 221,171) | M 273,961 | 5461 | 285 | 8 | Седан | 2006-2012 |
| MERCEDES-BENZ S-CLASS (W221) S 500 CGI (221,073, 221,173) | M 278,932 | 4663 | 320 | 8 | Седан | 2011-2013 |
| MERCEDES-BENZ S-CLASS (W221) S 450 (221,070, 221,170) | M 273,922 | 4663 | 250 | 8 | Седан | 2005-2013 |
| MERCEDES-BENZ S-CLASS (W221) S 400 Hybrid (221,095, 221,195) | M 272,974 | 3498 | 205 | 6 | Седан | 2009-2013 |
| MERCEDES-BENZ S-CLASS (W221) S 350 L (221,057, 221,157) | M 276,950 | 3498 | 225 | 6 | Седан | 2011-2013 |
| MERCEDES-BENZ S-CLASS (W221) S 350 (221,056, 221,156) | M 272,965 | 3498 | 200 | 6 | Седан | 2005-2013 |
| MERCEDES-BENZ S-CLASS (W221) S 300 (221,054) | M 272,946 | 2996 | 170 | 6 | Седан | 2006-2013 |
| MERCEDES-BENZ S-CLASS (W221) S 280 (221,054) | M 272,946 | 2996 | 170 | 6 | Седан | 2006-2013 |
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